Type I protein S deficiency and skin necrosis.

نویسندگان

  • A Craig
  • D A Taberner
  • A H Fisher
  • D N Foster
  • J Mitra
چکیده

A kindred with Type I protein S deficiency is described in which the index case developed skin necrosis during induction of oral anticoagulant therapy for deep venous thrombosis. Two other family members with protein S deficiency have been detected, and demonstrate the clinical variability of this condition.

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We report a case of a 6-year-old girl with severe protein S deficiency due to a homozygous mutation and recurrent episodes of skin necrosis. She developed purpura fulminans at birth and a catheter-related venous thrombosis complicated by massive pulmonary embolism at the sixth day of life. Long-term oral anticoagulant therapy with a vitamin K-antagonist was started with a therapeutic range of t...

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عنوان ژورنال:
  • Postgraduate medical journal

دوره 66 775  شماره 

صفحات  -

تاریخ انتشار 1990